South Korean international Ki has been one of the star performers at Sunderland since joining the Black Cats on a season-long loan in August.
Swansea have an option to recall Ki now as part of the agreement which took him to the North East — but Laudrup feels it would be unfair on the player to bring him back to Wales.
Swansea are without seven senior stars for this weekend's Old Trafford rematch, meaning the likes of Lee Lucas, Rory Donnelly and Dai Cornell may feature on an inexperienced bench.
Jonathan de Guzman (calf) and Dwight Tiendalli (hamstring) are the latest names on Swansea's injured list.
When asked whether he has considered bringing Ki, Laudrup said: "Yes and no. Of course it's a possibility, but there are a lot of things you have to take into consideration.
"Sunderland are last in the table, but they are in a cup semi-final and Ki is playing regularly.
"I don't think bringing him back would help either of us.
"If I bring him back he will sit on the bench and maybe play some games.
"Imagine then, if Sunderland go to the final, how that would affect the player mentally."
The good news for Swansea is that de Guzman and Tiendalli's problems are not thought to be serious, while Michel Vorm, Pablo Hernandez and Nathan Dyer are all making good progress.
And despite a shortage of options this weekend, Laudrup insists he has no regrets about working with only 22 senior players.
He argues most of the fitness troubles are the result of players having to play too often — but still feels that is preferable to carrying a bigger squad.
"It's normal to have these injuries when you have played as many games as we have," Laudrup said.
"But I prefer having a smaller squad even if it means having only 14, 15 or 16 players for a few games during a season, like we have this weekend and we had last weekend.
"The injuries have come because of the number of games and the lack of resting time we have had between them.
"But as long as they are just small injuries, which they are, we can cope."
Even with all the absentees, Laudrup is confident Swansea will field a "competitive" side as they go in search of a second victory at United in six days.
There are likely to be a number of changes from last Sunday's FA Cup triumph, with Angel Rangel, Ashley Williams, Ben Davies and Jose Canas all tipped to return.
"To win once at United is difficult, and to do it twice is even harder," Laudrup said.
"They will be desperate to end their losing run, but my players know they can win there now."