CAI Griffiths will start for the Ospreys in their derby against the Blues on Friday night.
The prop, who is back at the Liberty on a season-long loan, figures in the front row alongside Scott Baldwin and Duncan Jones.
Kahn Fotuali'i will captain the side from scrum-half.
Ospreys: Richard Fussell; Ross Jones, Tom Isaacs, Andrew Bishop, Eli Walker; Matthew Morgan, Kahn Fotuali'i (capt); Duncan Jones, Scott Baldwin, Cai Griffiths, Ian Gough, James King, George Stowers, Joe Bearman, Sam Lewis. Reps: Matthew Dwyer, Marc Thomas, Dmitri Arhip, Lloyd Peers, Morgan Allen, Rhys Webb, Sam Davies, Jonathan Spratt,