WING Tom Grabham makes his Heineken Cup debut when the Ospreys face Treviso on Sunday.
And there are also first Heineken Cup starts for lock Lloyd Peers and flanker Sam Lewis as the Ospreys look to end their pool campaign on a high.
Grabham comes in for Ross Jones, who is sidelined with an ankle injury.
Head coach Steve Tandy said: "We know that we're in for a tough afternoon on Sunday.
"Treviso are extremely physical, extremely tough, and they will want to finish on a high after games against Leicester and Toulouse where they've done really well but ended up with nothing.
"We know what a dangerous team they are, especially at home, so we are well aware that we will need to be focused and on top of our game if we are going to get the kind of performance that is needed to win there."
Ospreys: R. Fussell; T. Grabham, T. Isaacs, A. Bishop, E. Walker; D. Biggar, K. Fotuali'i (capt); D. Jones, S. Baldwin, A. Jones, L. Peers, J. King, J. Thomas, J. Bearman, S. Lewis. Reps: M. Dwyer, R. Bevington, C. Johnstone, I. Gough, G. Stowers, R. Webb, M. Morgan, J. Spratt.