GPs will be able to spend more time with patients following changes to their contract, says health officials.
Health Minister Mark Drakeford said the changes would help to improve services for both GPs and patients
The money GP surgeries received until now depended on how they performed against 969 different measures.
Under the new contract 300 measures will be cut, reducing form filling to free more time with patients, says the British Medial Association (BMA).
There will also be new financial incentives to encourage surgeries located close to each other to work together.
The new contract also aims to provide better care for people with early-stage cancer, for those at the end of their lives or the frail or elderly.
The Welsh government says the changes should help reduce the pressure on hospital A&E departments.
Charlotte Jones, chair of the BMA's Welsh GP committee, said the contract has "removed some of the bureaucratic tick-boxing type of medicine and targets that we've had to provide".
However the deal, which comes into effect in April, will not lead to weekend surgeries or more out-of-hours opening.
But Mr Drakeford insists patients will find it easier to get appointments with reduced red tape.
He said: “By changing the funding formula for practices, addressing the inequalities in health which exist between the most and least affluent areas of Wales.
“It makes perfect sense for GP practices to work with each other to provide a wider range of care within geographical areas, which we will see happen more as a result of changes to the contract.
“It is vital that local health boards continue to work closely and proactively with GP practices to support them in the delivery of the improvements in patient care through these changes to the contract.
“I would like to thank the General Practitioners Committee for their help in creating a solid basis for GP services in Wales for future years.”