JAMIE Roberts is a non-starter for the Blues in the Pro12 encounter against the Ospreys at the Millennium Stadium on Saturday.
The Wales centre, who featured in all five rounds of the Six Nations, has been struggling with a knee injury.
Alex Cuthbert is also sidelined after damaging a hamstring against England.
But Leigh Halfpenny and Sam Warburton both feature in a side that is captained from the centre by Gavin Evans.
The Blues have slipped to defeat in their last three Pro12 games and haven't beaten the Ospreys since 2010.
Cardiff Blues: L. Halfpenny;O. Williams; G. Evans (capt), D. Hewitt, H. Robinson; R. Patchell, L. Williams; S. Hobbs, M. Breeze, S. Andrews, F. Paulo, L. Rees, M. Paterson, L. Hamilton, S. Warburton. Reps: K. Dacey, T. Davies, T. Filise, R. Copeland, R. Watts-jones, L. Jones, C. Sweeney, G. Davies.